Vasotop tablets contain ramipril and are used for the treatment of congestive heart failure in dogs
General Characteristics: Ramipril, by the action of esterases, is hydrolyzed in the liver to its active metabolite, ramiprilat. This inhibits the angiotensin converting enzyme (ACE).
Pharmacodynamic characteristics: ECA catalyzes the conversion of angiotensin I to angiotensin II in blood plasma and endothelium, as well as the excision of bradykinin. Angiotensin II has a potent vasoconstrictive action while bradykinin is a vasodilator; so; the reduction in angiotensin II formation and the inhibition of bradykinin cleavage produce vasodilation.
Characteristics Pharmacokinetics: Ramipril is rapidly absorbed in the gastrointestinal tract after oral administration. The relative bioavailability of the different tablets has been studied, being in a range from 88 to 98%.
Interactions and incompatibilities:
Diuretics and low sodium diets potentiate the action of ACE inhibitors by activation of the renin-angiotensin-aldosterone system, so high doses of diuretics and low-sodium diets should be avoided during the use of the preparation to prevent hypotension.
Avoid the concomitant administration of potassium or potassium-sparing diuretics due to the risk of hyperkalemia.
Dogs: treatment of congestive heart failure.
Do not use in cases of hemodynamically relevant stenosis (aortic stenosis, mitral valve stenosis) or hypertrophic obstructive cardiomyopathy.
At the beginning of the treatment or after an increase in the dose there may be, exceptionally, a drop in blood pressure that may manifest with fatigue, lethargy or ataxia. In such cases, the treatment should be interrupted until normal conditions are restored and then restored to 50% of the initial dose. As with high doses of diuretics, a decrease in blood pressure may also occur. Therefore, in the first phase of treatment, the simultaneous administration of diuretics with ACE inhibitors should be avoided.
Route of administration:
Dogs: 0.125 mg ramipril / kg p.v./day.
The treatment should always be initiated with the lowest recommended dose. The dose should only be increased if the animal does not respond to the initial dose.
Depending on the severity of pulmonary congestion in dogs with cough or pulmonary edema, the dose may increase after two weeks to 0.25 mg ramipril / kg p.v./day.
In the absence of available information on the use of the preparation during pregnancy and lactation, the product should not be administered in pregnant or lactating females.
With veterinary prescription.
Cases with 28 tablets
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